GW2580 8.0m PoreGW2580 is a selective CSF 1R inhibitor for c FMS with IC50 of 30 nM, 150 to 500 fold selective compared to b Raf, CDK4, c KIT, c SRC, EGFR, ERBB2 4, ERK2, FLT 3, GSK3, ITK, JAK2 etc.
a natural alkaloid extracted from the Amaryllidaceae plant family
selective inhibitor with IC50 of 6 nM in cell-free assays
a monoterpene compound commonly found as major component of essential oils of several aromatic species
Taurolidine is a synthetic broad-spectrum antibiotic with antibacterial
Decitabine is a DNA methyltransferase inhibitor
Betulin (BE)
6-Dihydroxyanthraquinone) is a potent and specific inhibitor of cytochrome P-448 activity
sensitive to JAK2V617F and MPLW515L/K mutations
It is less potent to CDK7 and GSK3
and orally active FAK inhibitor
PX-478 2HCl is an orally active
and does not block cytochrome P450
